Cutaneous responses to vaccinia in individuals with previous smallpox vaccination - 19/08/11
Doi : 10.1016/j.jaad.2007.04.022
Eric L. Simpson, MD a, ⁎ 
, Michelle Hercher, BS b, Erika K. Hammarlund, MS c, Matthew W. Lewis, BS c, Mark K. Slifka, PhD c, Jon M. Hanifin, MD a
, Michelle Hercher, BS b, Erika K. Hammarlund, MS c, Matthew W. Lewis, BS c, Mark K. Slifka, PhD c, Jon M. Hanifin, MD a a From the Department of Dermatology
b School of Medicine, MS3
c Vaccine and Gene Therapy Institute, Oregon Health and Science University
Reprint requests: Eric L. Simpson, MD, Department of Dermatology, Oregon Health and Science University, Center for Health and Healing (CH16D), 3303 SW Bond Ave, Portland, OR 97239-4501.Portland, Oregon
Abstract |
The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.
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| Supported by National Institutes of Health grant AI063675 (Dr Slifka), Oregon National Primate Research Center grant RR00163 (Dr Slifka), and a Career Development Award from the Dermatology Foundation (Dr Simpson). Conflicts of interest: None declared. |
© 2007
American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 57 - N° 3
P. 442-444 - septembre 2007 Retour au numéro
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