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Journal of the American Academy of Dermatology
Volume 57, n° 3
pages 516-519 (septembre 2007)
Doi : 10.1016/j.jaad.2007.02.025
Case Reports

Photodynamic therapy for cutaneous verrucous carcinoma

Arjen F. Nikkels, MD, PhD , Laurence Thirion, MD, Pascale Quatresooz, MD, PhD, Gérald E. Piérard, MD, PhD
From the Department of Dermatopathology, University Hospital of Liège 

Reprint requests: Arjen F. Nikkels, MD, PhD, Department of Dermatopathology, University Hospital of Liège, CHU Sart Tilman, B-4000 Liège, Belgium.

Liège, Belgium


Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm follows a seemingly indolent progression and exhibits a low metastatic potential. Photodynamic therapy relies on the selective intratumoral cell accumulation and photoactivation of a photosensitizer, leading to the generation of phototoxic compounds responsible for necrosis and apoptosis of the target cells. An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 photodynamic therapy sessions administered at weekly intervals using methyl-aminolevulinate and 57-J/cm2 irradiations at 634-nm wavelength. The use of methyl-aminolevulinate–photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far. It may represent a convenient therapeutic alternative in this setting.

The full text of this article is available in PDF format.

Abbreviations used : ALA, HPV, MAL, PDT

 Funding sources: None.
Conflicts of interest: None declared.

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