Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study - 19/08/11
Résumé |
Purpose |
To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease.
Design |
Retrospective, population-based, case-control study.
Methods |
setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity.
Results |
HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively).
Conclusions |
Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls.
Le texte complet de cet article est disponible en PDF.Plan
Supported by Cecilia Vaughn Fellowship (T.P.), Direct Community Benefit Investment Kaiser Research Foundation Institute (D.C.G.), NIH Grants EY02162 and EY 10008 (T.P.M.), The Peierls Foundation, and a Research to Prevent Blindness Senior Scientific Investigator Award (T.P.M.). |
Vol 142 - N° 5
P. 745 - novembre 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?