Methotrexate-induced bullous acral erythema in a child - 21/08/11
, Sara Chaffee, MD b, James G.H. Dinulos, MD c
Correspondence to: Andrew E. Werchniak, MD, Brigham Dermatology Associates, 221 Longwood Avenue, Boston, MA 02115.Boston, Massachusetts, and Hanover and Lebanon, New Hampshire
Abstract |
Chemotherapy induced acral erythema (CIAE) is an uncommon and dramatic reaction to high-dose chemotherapy. It is characterized by symmetrical, well-demarcated, painful erythema of the palms and soles which may progress to bullae formation and desquamation. Prompt recognition and discrimination from more serious conditions such as graft-vs-host disease or toxic epidermal necrolysis is essential. This paper describes the case of a 12-year-old boy who developed CIAE after high-dose methotrexate treatment and discusses the important clinical, histopathological, and therapeutic features of this condition.
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| This supplement is made possible through the generous support of Stiefel Laboratories for the American Academy of Dermatology. Funding sources: None. Conflicts of interest: None identified. Reprints not available from the authors. |
Vol 52 - N° 5S
P. S93-S95 - mai 2005 Retour au numéro
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