Childhood neutrophilic eccrine hidradenitis: A clinicopathologic and immunohistochemical study of 10 patients - 21/08/11
Taipei, Taiwan
Abstract |
Background |
Neutrophilic eccrine hidradenitis (NEH) is occasionally reported in patients who have not received chemotherapy.
Objective |
The purpose of this study was to describe the clinicopathologic features of NEH occurring in healthy children and to investigate the interleukin (IL)-8 expression in the cutaneous lesions.
Methods |
Ten children with characteristic histologic features of NEH were collected from the Chang Gung Memorial Hospital. Their formalin-fixed, paraffin-embedded specimens were examined by immunohistochemical staining for IL-8.
Results |
The age of first presentation at our clinic ranged from 6 months to 14 months with a median age of 9.1 months. The onset of the disease clustered in the summertime. The most common clinical appearance was multiple erythematous papules and nodules on the limbs. Two of 7 biopsy specimens grew coagulase-negative Staphylococcus. None of patients had underlying systemic disease and all had complete resolution of the lesions within 3 weeks. Immunohistochemical staining for IL-8 was negative in the 10 cases studied.
Conclusion |
Childhood NEH appears as urticaria-like erythematous nodules and plaques on the limbs, trunk, or scalp. This benign and limited disease occurs with a predilection for summer months. In our study, onset was in children less than 15 months of age. IL-8 was not detected in the cutaneous lesions.
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Supported by the Chang Gung Medical Research Fund (CMRPG32006). Conflicts of interest: None identified. Presented in part at the 29th Annual Meeting of the Chinese Dermatological Society, Taipei, Taiwan, November 15, 2003. |
Vol 52 - N° 6
P. 963-966 - juin 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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