A clinician's paradigm in the treatment of atopic dermatitis - 21/08/11
Dallas, Texas
Abstract |
Successful management of atopic dermatitis requires a multipronged approach that includes skin barrier function care, use of topical or systemic agents, and identification and elimination of precipitating or exacerbating factors. Because the origin of atopic dermatitis is multifactorial and trigger factors differ among patients, treatment plans must be specific to the individual patient. This article offers an example of a permutational, or flexible, treatment paradigm. The approach utilizes 4 topical regimens—high-potency topical corticosteroids, lowest effective potency topical corticosteroids, topical calcineurin inhibitors (TCIs), or topical corticosteroid/TCI combinations—as initial therapy in a variety of induction protocols, as determined by the severity of a patient's condition and history. The paradigm permits treatment to progress from a chosen induction therapy to maintenance therapy. During the patient's induction therapy, as soon as an acceptable level of clearance is achieved, therapy should be adjusted to a maintenance regimen, such as monotherapy with either a TCI or a lowest effective potency topical corticosteroid (the latter used intermittently) or an alternation of the two agents. If there is no clearance or positive response with the initial induction protocol, the clinician should move to one of the alternative regimens.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AD, BMV, FDA, IFN-γ, IgE, PUVA, TCI, UVA, UVB
Plan
This article is part of a supplement supported by Connetics Corp, Palo Alto, California. Disclosure: Dr Abramovits has received research support and/or is a consultant and lecturer for Fujisawa Healthcare, Novartis Pharmaceuticals, GlaxoSmithKline, Ferndale Laboratories, Abbott Laboratories, Connetics Corp, and Galderma. |
Vol 53 - N° 1S
P. S70-S77 - juillet 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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