Microdermabrasion: A molecular analysis following a single treatment - 21/08/11
Ann Arbor, Michigan
Abstract |
Background |
Microdermabrasion is a popular method of superficial skin resurfacing. It is unclear if dermal remodeling actually occurs.
Objective |
To rigorously investigate the molecular alterations observed following a single microdermabrasion treatment.
Methods |
Forty-nine subjects received a single microdermabrasion treatment to buttock skin. Serial in vivo biochemical and immunohistological analyses were performed. Reverse transcriptase real-time polymerase chain reaction and immunohistochemistry assays were used to evaluate changes in transcription factors (AP-1, NF-κB), primary cytokines (interleukin-1β, tumor necrosis factor–⍺), matrix metalloproteinases (MMP-1, MMP-3, MMP-9), barrier repair enzymes (acetyl-coenzyme A carboxylase, 3-hydroxy-3-methylglutaryl coenzyme A reductase), and type I procollagen.
Results |
Elevation of transcription factors, primary cytokines, and matrix metalloproteinases occurs rapidly after a single microdermabrasion treatment. Two of 11 subjects also demonstrated increased type I procollagen messenger RNA and protein levels 14 days after treatment. No alteration in stratum corneum thickness was detected.
Conclusion |
Microdermabrasion activates a dermal remodeling/wound healing cascade with minimal epidermal disruption. Evidence now exists to further study manipulation of variables such as number and timing of microdermabrasion sessions.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AP, ATF, ERK, HMG CoA, IL, JNK, MAB, MAP, MMP, mRNA, NF, NICHD, OCT, RT-PCR, TNF-⍺
Plan
Supported by the Babcock Endowment for Dermatological Research at the University of Michigan, Bellamed Products, and Dermatology Foundation Patient Directed Investigation Grant to D. J. K. Bella Products donated the microdermabrasion machine, hand pieces, and crystals. Bella Products had no knowledge of the outcomes of this study. As a condition of acceptance of donations from Bella Products, the study was designed to be performed, analyzed, and reported solely by the faculty and staff of the Department of Dermatology at the University of Michigan. Conflicts of interest: None identified. A portion of the data herein was presented at the American Society for Dermatologic Surgery meeting in New Orleans, Louisiana, October 9, 2003. |
Vol 52 - N° 2
P. 215-223 - février 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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