Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors - 21/08/11
Staffordshire, Manchester, and West Midlands, United Kingdom
Abstract |
Background |
Patients with basal cell carcinoma (BCC) frequently develop further tumors during follow-up.
Objective |
We sought to elucidate the relative effects of pattern of ultraviolet radiation exposure, and site and histologic type of the first tumor, on the rate of increase in BCC numbers.
Methods |
We used negative binomial regression analysis to study the association of selected variables on the rate of increase in BCC numbers in 266 Caucasian patients who first presented with a tumor on the head/neck or trunk with nodular or superficial histology.
Results |
Patients with an initial truncal BCC with superficial histology demonstrated significantly faster increases in BCC numbers than did patients with other site and histology combinations.
Conclusions |
These data indicate that site and histology define subsets of patients with BCC.
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Supported by the Salford Cancer Research Fund and 3M Healthcare UK. Conflicts of interest: None identified. |
Vol 52 - N° 3
P. 468-473 - mars 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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