Pimecrolimus 1% cream for cutaneous lupus erythematosus - 24/08/11
Bochum, Germany, and Romford, United Kingdom
Abstract |
Topical treatment of cutaneous lupus erythematosus usually includes potent glucocorticosteroids. However, prolonged use causes adverse side effects including skin atrophy as the foremost concern. In contrast to glucocorticosteroids, the anti-inflammatory and immunosuppressive macrolactam pimecrolimus has no atrophogenic potential. Affected areas of 11 patients with different forms of lupus erythematosus were treated with pimecrolimus 1% cream under semiocclusive conditions twice daily for 3 weeks. Skin involvement before and after therapy was assessed by means of a clinical score. In all patients, significant regression of skin lesions was observed after therapy (P < .001). This was an open and uncontrolled study on a limited number of cases. We suggest that pimecrolimus 1% cream could be an efficacious and safe treatment option for cutaneous lupus erythematosus.
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Funding sources: None. Conflicts of interest: None identified. |
Vol 51 - N° 3
P. 407-410 - septembre 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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