Acute lymphoblastic leukemia presenting with urticarial plaques and hypereosinophilia in a child - 24/08/11
Seattle, Washington
Résumé |
Our report describes a previously healthy 10-year-old female who was seen for urticarial plaques and mild loss of appetite. An initial laboratory workup revealed an elevated leukocyte count of 30,000/μL and a peripheral eosinophil count of 22,500/μL. A skin biopsy showed a marked hypersensitivity tissue response with abundant eosinophils. Further investigation of her peripheral eosinophilia uncovered Giardia lamblia in a stool sample. Despite treatment with the anti-parasitic agent furazolidone, the patient's urticarial plaques, leukocyte count, and peripheral eosinophil count remained unchanged. A bone marrow biopsy confirmed a diagnosis of acute lymphoblastic leukemia (ALL). ALL with hypereosinophilia (ALL/Eo) represents a rare and distinct subset of ALL, with more than 30 cases documented in the literature. Our discussion summarizes the clinical aspects of this disease and reviews the reported dermatological manifestations of ALL/Eo.
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The pagination of this article was incorrect as originally published (2004:51;S79-S83). Please use the corrected page numbers listed online at http:www.eblue.org, in the corrected table of contents, or in the December 2004 index in future citations. This supplement is made possible through the generous support of Stiefel Laboratories for the American Academy of Dermatology. This work was previously presented in abstract form at the 2003 Society for Pediatric Dermatology meeting in Seattle, WA. |
Vol 51 - N° 5S
P. S151-S155 - novembre 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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