The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases - 24/08/11
Abstract |
Interleukin 10 (IL-10) is a key cytokine produced by a multitude of immune effector cells and possesses distinct regulatory effects on immune functioning in the skin. In this article we report the current understanding of the immunobiology of IL-10 and identify the role of IL-10 in cutaneous infection as well as in autoimmune and neoplastic processes. We reviewed the literature to examine the function of IL-10 in different cutaneous disorders. IL-10 can influence and potentially treat T1/T2 differentiation, antigen-presenting cell functioning, antigen-presenting cell–mediated T-cell activation, and T-cell, B-cell, and mast cell growth and differentiation that is aberrant in various disease processes. The literature consensus is that the multitude of effects of IL-10 contribute to the pathogenesis of different skin disorders. In certain circumstances IL-10 could represent novel therapeutic approaches to treating cutaneous diseases.
Learning objective |
At the conclusion of this learning activity, participants should be acquainted with the role of IL-10 in many infectious diseases, autoimmune skin disease, inflammatory processes, and malignancy. Its possible role in the resolution of various skin diseases should be better understood.
Le texte complet de cet article est disponible en PDF.Abbreviations : AD, APC, BP, CHS, CSF, DC, DTH, HAART, IFN, Ig, IL, JAK, LC, MF, mRNA, NMSC, NK, OV, PBMC, PV, SCC, SLE, SOCS, SSc, STAT, TGFβ, Th, TNF, UV, VL
Plan
Vol 50 - N° 5
P. 657-675 - mai 2004 Retour au numéro
- CME examination : Identification No. 804-105 Instructions for Category I CME credit appear in the front advertising section. See last page of Contents for page number
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