Compound melanocytic nevi with granular cell changes - 24/08/11
Doi : 10.1016/j.jaad.2003.11.068
Hatem M El-Gamal, MD a, Leslie Robinson-Bostom, MD b, ⁎ 
, Kirk D Saddler, MD b, Teddy Pan, MD b, Martin C Mihm, MD c
, Kirk D Saddler, MD b, Teddy Pan, MD b, Martin C Mihm, MD c a Department of Dermatology Indiana University, School of Medicine, Indianapolis,, Indiana, USA
b Department of Dermatology Brown Medical School, Providence, Rhode Island, USA
c Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachussetts, USA
*Correspondence to: Leslie Robinson-Bostom, MD, Brown Medical School, Department of Dermatology, APC-10, 593 Eddy St, Providence, RI 02903, USA.
Abstract |
Two cases of compound melanocytic nevi with granular cell changes were studied. Histological examination revealed compound melanocytic nevi with a portion of the dermal component exhibiting a sheet like proliferation of nevoid cells with granular cytoplasm. Immunohistochemically, both populations of cells stained positive for S-100 and Melan-A. However, HMB-45 was positive only for the nevus cells with granular cytoplasm. We believe this represents granular cytoplasmic changes of nevus cells and does not denote malignant transformation.
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 | Funding sources: None. Conflicts of interest: None identified. Reprints not available from authors. |
© 2004
American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 50 - N° 5
P. 765-766 - mai 2004 Retour au numéro
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