Pathogenesis of androgenetic alopecia - 24/08/11
Abstract |
Although it is universally accepted that dihydrotestosterone causes baldness, how it does so is not well understood. I propose that 3 mechanisms are at work: miniaturization by a dihydrotestosterone-induced acceleration of the mitotic rate of the matrix that leaves less and less time for differentiation; an increased telogen shedding as a result of the shortening of the hair cycles that increases the telogen number per unit of time; and the increased number and duration of the lag phase or kenogen. That this last mechanism is related to dihydrotestosterone is unclear.
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Funding sources: None. Conflicts of interest: None identified. |
Vol 50 - N° 5
P. 777-779 - mai 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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