Adherence to topical therapy decreases during the course of an 8-week psoriasis clinical trial: Commonly used methods of measuring adherence to topical therapy overestimate actual use - 24/08/11
Winston-Salem, North Carolina, and Houston, Texas
Abstract |
Introduction |
Medication nonadherence is common throughout medicine, and research into this area is increasing; however, knowledge about topical medication adherence is limited.
Methods |
A total of 30 patients were enrolled in a clinical trial for psoriasis and followed up for 8 weeks using 3 methods of adherence monitoring: electronic monitoring caps; medication logs; and medication usage by weight.
Results |
Adherence rates calculated from the medication logs and medication weights were consistently higher than those of the electronic monitors (P < .05). Electronically measured adherence rates declined from 84.6% to 51% during the 8-week study (P < .0001). Female sex and increasing age by 1 year predicted improved adherence of 5% and 0.8%, respectively (P < .0001). The number of treatment gaps increased from the first half to the last half of the study, and weekend days were overrepresented in treatment gaps.
Conclusion |
Medication logs and weights do not ensure medication adherence to topical therapy. Electronic monitoring allows a more precise method of adherence measurement.
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Supported in part by Fujisawa Healthcare, Inc. Conflicts of interest: None identified. |
Vol 51 - N° 2
P. 212-216 - août 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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