Hydroxyurea-associated squamous dysplasia - 24/08/11
Chicago, Illinois
Abstract |
We report 2 cases of squamous dysplasia associated with long-term hydroxyurea therapy. The association between hydroxyurea and multiple aggressive squamous cell carcinomas, Bowen's disease, and multiple actinic keratoses in sun-exposed areas after a variable latency period has been increasingly reported. On reviewing the literature, 17 cases were identified and are reviewed, with emphasis on possible pathogenetic mechanisms of carcinogenicity. Squamous dysplasia, a precursor state to a more aggressive condition of multiple squamous cell carcinomas in photoexposed areas, should be added to the well-known cutaneous toxicities of hydroxyurea therapy.
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Funding sources: None. Conflicts of interest: None identified. Presented in part at the International Society of Dermatopathology Meeting in Washington, DC, 2001. |
Vol 51 - N° 2
P. 293-300 - août 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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