Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis - 24/08/11
Reprint requests: Francisco A. Tausk, MD, Department of Dermatology, Johns Hopkins Medical Institutions, 550 N. Broadway St, Suite 1002, Baltimore, MD 21205.Baltimore, Maryland; Chicago, Illinois; Houston, Texas; and Weston, Florida
Abstract |
Background |
Physical and emotional stressors have been found to mediate a wide variety of biological changes including the facilitation of tumor progression; however most of these paradigms utilized artificial sources of neoplasms and stress.
Methods |
Skh mice were exposed to carcinogenic doses of ultraviolet light (UV). The stressed group was subjected to the close proximity of fox urine as a source of stress from the presence of the odor of their natural predator, while the control group remained stress free.
Results |
A significant acceleration in the development of cutaneous neoplasms was observed in mice that had been exposed to the stressor. The first tumor appeared in the group after 8 weeks, whereas nonstressed mice began to develop these by week 21.
Conclusion |
These results suggest that stress plays a role in potentiating cutaneous carcinogenesis.
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| Supported in part by funds from the Johns Hopkins Cancer Center for Complementary and Alternative Medicine. Conflicts of interest: None identified. Presented in part at the annual meeting of the Association for Psychocutaneous Medicine of North America, San Francisco, March 2003. |
Vol 51 - N° 6
P. 919-922 - décembre 2004 Retour au numéro
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