Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata - 24/08/11
Abstract |
We report the results of a pilot study of topical 5% 5-fluorouracil (FU) cream for the treatment of alopecia areata, an immunologically modulated disorder of hair growth. Patients with extensive (>50% scalp surface area involvement) alopecia areata that was refractory to previous treatments applied 5-FU to one side of their scalp twice daily for 3 to 6 months. In all, 9 patients enrolled, and 8 completed the study. No patient experienced measurable hair growth on the treated side. Only mild irritation was observed in a subset of patients with application of 5-FU to the nonphotodamaged scalp skin. Based on these results, we cannot recommend the use of topical 5-FU for treatment of alopecia areata without further evidence of therapeutic benefit.
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Study medication and a small stipend were provided by ICN Pharmaceuticals. Conflicts of interest: None identified. |
Vol 50 - N° 6
P. 941-943 - juin 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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