Recommendations of the French Society for Rheumatology. TNFα antagonist therapy in rheumatoid arthritis - 01/01/06
on behalf of the Rheumatism and Inflammation Club (CRI) and of the French Society for Rheumatology
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Abstract |
Objectives |
To develop recommendations for TNF-antagonist therapy in patients with rheumatoid arthritis (RA) seen in everyday practice, under the aegis of the French Society for Rheumatology.
Method |
We used the methods recommended by the French Agency for Healthcare Accreditation and Evaluation, the AGREE collaboration, and the European League against Rheumatism (EULAR). The recommendations focus on patient selection, monitoring, and treatment adjustments.
Results |
Criteria for selecting patients eligible for TNF-antagonist treatment of RA include: 1) a definitive diagnosis of RA; 2) disease activity for longer than 1 month, including presence of objective signs of inflammation; or radiographic progression; 3) previous failure of methotrexate in the highest tolerated dosage or of another disease-modifying antirheumatic drug in patients with contraindications to methotrexate; 4) absence of contraindications to TNF-antagonist therapy. When starting TNF-antagonist therapy 1) a thorough baseline evaluation should be conducted; 2) any of the three available agents can be used, as no differences in efficacy have been identified in patient populations; 3) concomitant methotrexate therapy is recommended regardless of the TNF antagonist used; and 4) patients should receive standardized follow-up at regular intervals. Treatment adjustments should be based on the following: 1) the treatment objective is achievement of a EULAR response; 2) when such a response is not achieved, the dosage or dosing interval can be changed, or the patient can be switched to another TNF antagonist; 3) in patients who experience intolerance to a TNF antagonist, another TNF antagonist may be tried, depending on the nature of the adverse event; 4) occurrence of a remission should lead to a reduction in symptomatic medications, most notably glucocorticoids where used; in the event of a prolonged remission, either the TNF antagonist or the concomitant disease-modifying antirheumatic drug may be reduced.
Conclusion |
These recommendations are intended to help physicians use TNF antagonists in their everyday practice with RA patients. They do not constitute regulations.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, TNFalpha antagonists, Recommendations, Clinical practice, Treatment, Disease-modifying antirheumatic drugs
Plan
Vol 73 - N° 4
P. 433-441 - juillet 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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