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Journal of the American Academy of Dermatology
Volume 48, n° 4
pages 525-529 (avril 2003)
Doi : 10.1067/mjd.2003.107
accepted : 5 April 2002
Lupus-associated toxic epidermal necrolysis: A novel manifestation of lupus?

Rochelle Mandelcorn, MD, FRCPC, Neil H. Shear, MD, FRCPC
Toronto, Ontario, Canada 
From the Division of Dermatology, Department of Medicine, University of Toronto 


Background: Toxic epidermal necrolysis is an acute mucocutaneous reaction characterized by extensive cutaneous and mucosal sloughing and systemic involvement. It is generally associated with drug ingestion. Objective and Methods: We describe 2 patients who developed typical clinical and histopathologic features of toxic epidermal necrolysis with unusual subacute progression, absence of systemic involvement or high-risk drug ingestion, and features of lupus erythematosus. Conclusion: We propose that this constellation of features represents a new entity not previously described. This entity may represent a more severe variant of Rowell's syndrome or, alternatively, a novel manifestation of lupus erythematosus (J Am Acad Dermatol 2003;48:525-9.)

The full text of this article is available in PDF format.

 Funding sources: None.
 Conflict of interest: None identified.
 Reprint requests: Neil H. Shear, Division of Dermatology, Sunnybrook & Women's College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5. E-mail:
 0190-9622/2003/$30.00 + 0

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