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Journal of the American Academy of Dermatology
Volume 48, n° 4
pages 617-619 (avril 2003)
Doi : 10.1067/mjd.2003.36
Palpebral edema as a cutaneous manifestation of hyperthyroidism

Tetsuya Higuchi, MD, PhDa, Takahiro Satoh, MD, PhDa, Hiroo Yokozeki, MD, PhDa, Ichiro Katayama, MD, PhDb, Kiyoshi Nishioka, MD, PhDa
Tokyo and Nagasaki, Japan 
From the Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University,a and the Department of Dermatology, Nagasaki University School of Medicineb 


Three cases of palpebral edema associated with Graves' disease are described. These patients had unilateral edema and minimal erythema of the upper eyelid. Notable was that, histologically, dermal edema and dilation of lymphatic vessels were observed, but deposition of mucopolysaccharides was not. In 2 cases, edema of the eyelid was resistant to treatment with an antithyroid drug. Unilateral edema of the upper eyelid is an important cutaneous manifestation that indicates the presence of hyperthyroidism. (J Am Acad Dermatol 2003;48:617-9.)

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 Conflict of interest: None reported.
 Reprint requests: Tetsuya Higuchi, MD, PhD, Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. E-mail:
 0190-9622/2003/$30.00 + 0

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