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Journal of the American Academy of Dermatology
Volume 48, n° 4
pages 623-625 (avril 2003)
Doi : 10.1067/mjd.2003.170
Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky, MDd, Julia Welzel, MDa, Masayuki Amagai, MD, PhDb, Detlef Zillikens, MDc, Thorsten Wygold, MDa,b,c,d
Luebeck and Wuerzberg, Germany, and Tokyo, Japan 
From the Departments of Dermatology, University of Luebeck,a Keio University, Tokyo,b and University of Wuerzburgc; and the Department of Pediatrics, University of Luebeck.d 


We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates. (J Am Acad Dermatol 2003;48:623-5.)

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 Funding sources: None.
 Conflict of interest: None identified.
 Reprint requests: Thomas Parlowsky, MD, Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany. E-mail:
 0190-9622/2003/$30.00 + 0

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