Normolipemic plane xanthoma associated with adenocarcinoma and severe itch - 29/08/11
Abstract |
Normolipemic plane xanthomas are yellow-red-colored flat patches or plaques with barely palpable borders, under normolipemic conditions usually involving the eyelids, the lateral sides of the neck, the upper aspect of the trunk, or the flexural folds. Histologically the lesions are characterized by an infiltrate consisting of foamy macrophages in the papillary and middermis with a distinct perivascular localization. Plane xanthoma has been associated with monoclonal gammopathy, cryoglobulinemia, and myeloproliferative disorders. We present a patient in whom plane xanthoma developed on the upper aspect of the back, which was accompanied by severe itch in the affected area. These symptoms started 1 month after resection of an adenocarcinoma of the rectum that was complicated by recurrent abdominal abscesses and, currently, by ongoing inflammatory bowel disease. A hypothetic pathophysiologic scheme of events leading to xanthoma formation in this patient is presented. (J Am Acad Dermatol 2003;49:119-22.)
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Funding sources: None. |
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Conflict of interest: None identified. |
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Reprint requests: Errol P. Prens, MD, PhD, Department of Dermatology, Ziekenhuis Walcheren, Koudekerkseweg 88, 4382 EE Vlissingen, The Netherlands. E-mail: e.prens@erasmusmc.nl. |
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0190-9622/2003/$30.00 + 0 |
Vol 49 - N° 1
P. 119-122 - juillet 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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