Analysis of long-term outcomes of combined modality therapy for cutaneous T-cell lymphoma - 29/08/11
Abstract |
Background: Although cutaneous T-cell lymphoma (CTCL), including mycosis fungoides (MF) and Sézary syndrome, is often responsive to treatment, few current therapies increase survival or consistently induce durable remissions, especially in advanced disease. Objective: In an effort to improve treatment efficacy and outcome in CTCL, a combined modality protocol using 3 to 4 consecutive phases of therapy was initiated in 1987 at M.D. Anderson Cancer Center, Houston, Tex. Methods: During a period of 15 years between 1987 and 2001, 95 patients with early-stage (Ia-IIa, n = 50) and late-stage (IIb-IVb, n = 45) MF were treated with subcutaneous interferon-⍺ and oral isotretinoin, followed by total-skin electron beam therapy, and long-term maintenance therapy with topical nitrogen mustard and interferon-⍺. Patients with late-stage (IIb-IVb) disease also received 6 cycles of combination chemotherapy before electron beam therapy. Results: Combined modality therapy yielded a response rate of 85% with a 60% complete response rate. Among 38 patients with early-stage disease and 18 patients with late-stage disease achieving complete response, 9 (24%) patients with early-stage MF and 3 (17%) patients with late-stage MF achieved sustained remissions lasting more than 5 years. The median disease-free survival (DFS) for early and late stages of disease was 62 and 7 months, with 5-year Kaplan-Meier estimated rates of 50% and 27%, respectively. Current median overall survival times on combined modality are 145 months for patients with early-stage disease and 36 months for those with late-stage disease. Death was attributable to CTCL disease in 17 (55%) of 31 cases. The Kaplan-Meier estimates for 5-year survival are 94% for early-stage and 35% for late-stage disease. Univariate survival analysis in this patient population reveals statistically significant associations of clinical stage with overall response rates (P = .02), DFS (P = .03), and overall survival (P < .0001); age with DFS (P = .001) and overall survival (P = .04); and T stage (P < .0001) and lactate dehydrogenase (P = .007) with overall survival. By multivariate analysis using a Cox proportional hazards model, only age was significantly associated with DFS (hazard ratio 2.9), and only stage with overall survival (hazard ratio 18.2). Conclusion: This nonrandomized and uncontrolled CTCL study gives supportive evidence that this multiphased combined modality regimen is well tolerated and may yield higher response rates and DFS than total-skin electron beam therapy alone, but provides no evidence for a change in survival. (J Am Acad Dermatol 2003;49:35-49.)
Le texte complet de cet article est disponible en PDF.Abbreviations : ABV, AML, CI, CMED, CR, CTCL, DFS, ECP, IFN, IV, LDH, MDACC, MF, M.U., NCI, OR, PR, PUVA, SIL-2R, SS, TSEB
Plan
Supported in part by the Burnell Chaney CTCL Patient Education Fund, the Sherry L. Anderson CTCL Research Fund, the core grant to MDACC CA-16672, NIH grant R01-CA74117, and K24 CA-86815. |
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Conflict of interest: None identified. |
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Reprint requests: Madeleine Duvic, MD, M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 434, Houston, TX 77030-4095. |
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0190-9622/2003/$30.00 + 0 |
Vol 49 - N° 1
P. 35-49 - juillet 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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