Effects of topical l-selenomethionine with topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice - 29/08/11
Abstract |
Background |
The antioxidants selenium and vitamin E can be effective in reducing acute and chronic ultraviolet (UV)-induced skin damage.
Objective |
This study investigated whether topical l-selenomethionine with topical RRR-⍺-tocopherol (Eol) or oral RRR-⍺-tocopheryl acetate (Eac) can reduce the incidence of UV-induced skin damage more than treatment with each alone.
Methods |
Skh:2 hairless pigmented mice were treated with lotion vehicle, l-selenomethionine lotion, Eol lotion, oral Eac, l-selenomethionine plus Eol lotion, or l-selenomethionine lotion plus oral Eac and exposed to UVB. Skin pigmentation was scored, and the number of skin tumors per animal was counted weekly.
Results |
Mice treated with selenium and vitamin E had significantly less acute and chronic UV-induced skin damage.
Conclusion |
Topical l-selenomethionine alone and combined with vitamin E gave the best protection against UV-induced blistering and pigmentation. In protecting against skin cancer, topical Eol and topical l-selenomethionine plus oral Eac were best. Significant synergy of l-selenomethionine with vitamin E was not observed.
Le texte complet de cet article est disponible en PDF.Abbreviations : Eac, Eol, UV
Plan
 | Funding sources: Henkel Corporation grant and the Karen E. Burke Research Fund. Conflict of interest: None identified. |
Vol 49 - N° 3
P. 458-472 - septembre 2003 Retour au numéro
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