Lymphomatoid papulosis associated with mycosis fungoides: a study of 21 patients including analyses for clonality - 29/08/11
, Carol Jones, BA c, Philip E LeBoit, MD a, b, Mohammed Kashani-Sabet, MD a, Timothy H McCalmont, MD a, b, James Zehnder, MD bAbstract |
Background |
Although an association of lymphomatoid papulosis (LyP) with mycosis fungoides (MF) is recognized, our understanding of this relation is limited.
Objective |
We sought to document the clinical experience at the University of California, San Francisco, in 21 patients who had both LyP and MF and to do clonality studies in 7 of those patients in whom this was possible.
Methods |
We conducted chart review of the 21 patients and analysis for T-cell receptor-γ gene rearrangements by the polymerase chain reaction.
Results |
Of 54 patients, 21 (39%) with LyP had associated MF. LyP preceded MF in 14 (67%), MF preceded LyP in 4 (19%), and there was concurrent appearance in 3 (14%). Of the 21 patients, 20 (95%) were type A and only 1 (5%) was type B. An identical clone was found in lesions of both LyP and MF in all 7 patients in whom analysis was possible.
Conclusion |
Findings of this study strengthen the idea that LyP and MF are related T-cell lymphoproliferative disorders.
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 | Dr Kashani-Sabet is supported by the Herschel and Diana Zackheim Endowment. Conflicts of interest: None identified. |
Vol 49 - N° 4
P. 620-623 - octobre 2003 Retour au numéro
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