Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study - 29/08/11
Abstract |
This multicenter, randomized, investigator-blinded study investigated the efficacy and tolerability of adapalene gel 0.1% plus clindamycin phosphate lotion 1%, compared with clindamycin plus vehicle for the treatment of mild to moderate acne vulgaris. A total of 249 patients applied clindamycin lotion twice daily and adapalene (125 patients) or vehicle gel (124 patients) once daily for 12 weeks. A significantly greater reduction of total (P < .001), inflammatory (P = .004) and noninflammatory lesions (P < .001) was seen in the clindamycin plus adapalene group than in the clindamycin plus vehicle group. These significant treatment effects were observed as early as week 4 for both noninflammatory and total lesion counts. Both treatment regimens were well tolerated. Although the worst scores for scaling (P < .05), dryness (P < .01), and stinging/burning (P < .05) were higher in the clindamycin plus adapalene group than in the clindamycin plus vehicle group in patients with moderate or severe irritation; in most cases these symptoms were of mild intensity.
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This article is part of a supplement supported by an educational grant from Galderma International. Funding source: Galderma International funded the research reported here. |
Vol 49 - N° 3S
P. S211-S217 - septembre 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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