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Journal of the American Academy of Dermatology
Volume 48, n° 2S
pages 35-38 (février 2003)
Doi : 10.1067/mjd.2003.114
Keratoacanthoma developing in sites of previous trauma: A report of two cases and review of the literature

Sean F. Pattee, BS, Nancy G. Silvis, MD
Section of Dermatology, University of Arizona College of Medicine. Tucson, Arizona 


Keratoacanthoma is a common benign squamous neoplasm that only rarely progresses to metastatic carcinoma. The cause of keratoacanthoma is unclear; however, suspected causes include ultraviolet light, genetic factors, immunosuppression, chemical carcinogens, viruses, and trauma. Keratoacanthomas have been reported only rarely to arise in sites of previous trauma. We report 2 cases of keratoacanthomas arising shortly after episodes of cutaneous trauma and provide a review of the literature of similar cases previously reported. It is likely that an interaction exists between a variety of factors in the development of keratoacanthomas; however, it appears that a predilection exists for these lesions to arise in trauma sites. (J Am Acad Dermatol 2003;48:S35-8.)

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 This supplement is made possible through an unrestricted educational grant from Stiefel Laboratories to the American Academy of Dermatology.
 Reprint requests: Nancy G. Silvis, MD, 1501 N Campbell Ave, PO Box 245038, Tucson, AZ 85724. E-mail:
 0190-9622/2003/$30.00 + 0

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