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Journal of the American Academy of Dermatology
Volume 46, n° 2
pages 215-217 (février 2002)
Doi : 10.1067/mjd.2002.118540
accepted : 18 June 2001
Cutaneous sensory nerve fibers are decreased in number after peripheral and central nerve damage
 

Joanna Wallengren, MD, PhDa, Eva Tegner, MD, PhDa, Frank Sundler, PhDb
Lund, Sweden 
From the Departments of Dermatologya and Neuroendocrine Cell Research,b University Hospital 

Abstract

Two dermatologic patients displaying peripheral and central nerve damage, respectively, are described. Cutaneous nerve fibers in both patients were studied in skin biopsy specimens taken from neuropathic areas and from the contralateral side, immunocytochemistry being applied to a pan-neuronal marker, a protein gene-product (PGP 9.5). One of the patients, suffering from compression of the ulnar nerve, had dyshidrotic eczema of the hands that was absent on areas of skin that were neuropathic. The cutaneous innervation (most of which was sensory) was reduced by 50% in the neuropathic area as compared with the contralateral side. The other patient had unilateral pruritus on the parethic side after a stroke. The cutaneous innervation of that side was reduced by 80% as compared with the other side. It seems that peripheral sensory innervation is a prerequisite for inflammation, whereas spontaneous itching may emanate from a central nervous system disorder such as a stroke and continue on in partly denervated skin. (J Am Acad Dermatol 2002;46:215-7.)

The full text of this article is available in PDF format.

 Reprint requests: Joanna Wallengren, MD, PhD, Department of Dermatology, University Hospital, SE-221 85 Lund, Sweden.



© 2002  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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