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Journal of the American Academy of Dermatology
Volume 46, n° 2
pages 251-255 (février 2002)
Doi : 10.1067/mjd.2002.118552
Low-dose ultraviolet A1 phototherapy for extragenital lichen sclerosus: Results of a preliminary study
 

Alexander Kreuter, MD, Thilo Gambichler, MD, Annelies Avermaete, MD, Marcus Happe, MD, Martina Bacharach-Buhles, MD, Klaus Hoffmann, MD, Thomas Jansen, MD, Peter Altmeyer, MD, Gregor von Kobyletzki, MD
Department of Dermatology and Allergology, Ruhr-University Bochum. Bochum, Germany 

Abstract

Background: Lichen sclerosus (LS) is a chronic inflammatory skin disease in which numerous therapies have been used, with only limited success. Because low-dose UVA1 phototherapy has been shown to be an effective treatment option for localized scleroderma, which shares several similar clinical and histologic features with LS, we initiated a clinical trial with this phototherapeutic modality in patients with LS. Methods: Ten patients suffering from extragenital LS were treated with low-dose UVA1 phototherapy 4 times weekly with single UVA1 doses of 20 J/cm2. Forty treatment sessions were performed within 10 weeks, resulting in a cumulative UVA1 dose of 800 J/cm2. Results: Low-dose UVA1 phototherapy resulted in a marked reduction of the clinical score and a significant (P < .05) decrease of ultrasonographically measured skin thickness as well as a highly significant (P < .001) increase of dermal density. The patients reported a remarkable softening and repigmentation of the affected skin. Conclusion: Analogous to the treatment results in localized scleroderma, low-dose UVA1 phototherapy seems to be an effective and well-tolerated treatment option for extragenital LS. (J Am Acad Dermatol 2002;46:251-5.)

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 Funding sources: None.
 Conflicts of interest: None.
 Reprint requests: Alexander Kreuter, MD, Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, D-44791 Bochum, Germany. E-mail: a.kreuter@derma.de.



© 2002  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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