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Journal of the American Academy of Dermatology
Volume 46, n° 2
pages 297-300 (février 2002)
Doi : 10.1067/mjd.2002.104966
Cutaneous metastasis from an intracranial glioblastoma multiforme

Patricio Figueroa, MDa, Jason R. Lupton, MDa, Todd Remington, MDa, Michael Olding, MDb, Robert V. Jones, MDc, Laligam N. Sekhar, MDd, Virginia I. Sulica, MDa
Washington, DC, and Fairfax, Virginia 
From The Department of Dermatology,a the Division of Plastic Surgery,b the Department of Pathology,c The George Washington University Medical Center, and the Mid-Atlantic Brain and Spine Institutes,d Fairfax 


A 34-year-old white man with a history of an intracranial glioblastoma multiforme was treated with surgical excision and radiotherapy. Five months later, the patient had a rapidly growing scalp mass develop. This lesion was excised, and the histology revealed a tumor that was similar to the originally resected intracranial glioblastoma. Immunohistochemistry for general neuroepithelial derivation (S-100 protein) and for glial fibrillary acidic protein (GFAP) was positive, whereas mesenchymal, epithelial, and neuronal markers were negative. This immunohistochemistry pattern was identical to the original tumor. Although metastasis of this tumor is not uncommon, metastasis to the skin has never been reported. To our knowledge, this is the first reported case of cutaneous metastasis from glioblastoma in the world literature. (J Am Acad Dermatol 2002;46:297-300.)

The full text of this article is available in PDF format.

 Reprint requests: Jason R. Lupton, MD, The George Washington University Medical Center, 2311 M St, NW, Washington, DC 20037. E-mail:

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