Treatment of vitiligo with the 308-nm excimer laser: A pilot study - 01/09/11
Abstract |
Background: Present vitiligo therapies require many months of treatment and often result in disappointing outcomes. Common therapeutic options include phototherapy with psoralens plus ultraviolet A (UVA) radiation and broadband or narrowband UVB radiation phototherapy. Some of these modalities require regular phototherapy sessions several times a week for up to a year to achieve a therapeutic response. Targeted phototherapy with single-wavelength laser light is a treatment alternative that may prove to be a time-efficient and effective therapeutic option for the management of vitiligo. Methods: This intervention study was designed as a before and after trial with a single arm. Twenty-nine patches of vitiligo from 18 patients (6 males and 12 females) were treated at the start of the study. Vitiligo patches were treated by using a 308-nm xenon-chloride excimer laser. Lesions were treated 3 times a week for a maximum of 12 treatments. Treatment was withheld if sunburn was observed and held until resolution. All patients had untreated vitiligo patches that served as control sites. Results: Twenty-three vitiligo patches from 12 patients received at least 6 treatments and resulted in some repigmentation in 57% of the treated patches. Eleven vitiligo patches from 6 patients received all 12 treatments and resulted in some repigmentation in 82% of the treated patches. Untreated control patches remained unchanged. Conclusion: This degree of repigmentation in a period of 2 to 4 weeks is much higher than that achieved with any other present vitiligo therapy. The xenon-chloride excimer laser may represent a new treatment modality for the management of stable vitiligo. (J Am Acad Dermatol 2002;46:727-31.)
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Funding sources: Use of the 308-nm laser provided by Surgilight Inc, Winter Park, Florida. |
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Disclosure: Dr Spencer and the Mount Sinai School of Medicine have applied for a use patent of the excimer 308-nm laser for the treatment of vitiligo. |
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Reprint requests: James M. Spencer, MD, MS, Department of Dermatology, Mount Sinai School of Medicine, 5 E 98th St, 5th Floor, New York, NY 10029. |
Vol 46 - N° 5
P. 727-731 - mai 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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