Cutaneous natural killer/T-cell lymphoma - 01/09/11
Abstract |
Lymphomas are classified as either Hodgkin's or non-Hodgkin's. The 2 subtypes of non-Hodgkin's lymphoma that can present primarily in the skin are cutaneous T-cell lymphoma and cutaneous B-cell lymphoma, both of which tend to be low-grade malignant neoplasms. Recently another distinct subtype of lymphoma was discovered, the natural killer (NK)/T-cell lymphoma, which can involve the skin in a primary or secondary fashion. The NK/T-cell subtype of lymphoma is characterized by the expression of the NK-cell antigen CD56. These CD56+ lymphomas are further subdivided into nasal NK/T-cell lymphomas that commonly present as midfacial destructive disease and non-nasal NK/T-cell lymphomas that often arise in extranodal locations, including the skin. We report a case of aggressive NK-cell leukemia/lymphoma with numerous secondary cutaneous lesions and review the clinical and histopathologic spectrum of non-nasal CD56+ lymphomas, with an emphasis on the dermatologic findings. (J Am Acad Dermatol 2002;46:451-6.)
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Funding sources: None. |
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Conflict of interest: None. |
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Reprint requests: Rossitza Lazova, MD, Yale Dermatopathology Laboratory, PO Box 208059, 15 York St, New Haven, CT 06520-8059. E-mail: rossitza.lazova@yale.edu. |
Vol 46 - N° 3
P. 451-456 - mars 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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