Generalized hyperpigmentation with daunorubicin chemotherapy - 01/09/11
Abstract |
Daunorubicin has been reported to cause hyperpigmentation of sun-exposed skin and/or transverse nail pigmentation (3 cases). We report a case of an African American man who had an atypical pattern of generalized hyperpigmentation develop that involved many sun-protected skin areas 2 weeks after daunorubicin treatment. Histopathology of hyperpigmented skin showed increased melanin granules in all epidermal layers. The mechanisms by which daunorubicin may increase skin pigmentation are discussed. (J Am Acad Dermatol 2002;46:S1-3.)
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This supplement is made possible through an unrestricted educational grant from Stiefel Laboratories to the American Academy of Dermatology. |
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Reprint requests: George Kroumpouzos, MD, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 45 Francis St, Boston, MA 02115. E-mail: kroumpouzos.george@boston.va.gov. |
Vol 46 - N° 2S
P. S1-S3 - février 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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