Treatment of childhood mycosis fungoides with topical PUVA - 01/09/11
Abstract |
Mycosis fungoides is the most common type of cutaneous T-cell lymphoma, which is usually observed in mid to late adulthood. We report 5 cases of mycosis fungoides in children, all presenting as patch- and plaque-stage disease most commonly involving the buttocks. Histologic examination showed in every case the typical features of mycosis fungoides. In 4 of the 5 cases, the infiltrating lymphocytes were characterized by the T-cell phenotype CD3+, CD4+, CD8+; and in 3 cases, a monoclonal rearrangement of the T-cell receptor gamma (TCR-γ) gene was found. Three children received topical PUVA treatment, and the other two were treated with mid-potency topical corticosteroids, resulting in complete clinical remission. A management approach to mycosis fungoides with topical PUVA may be appropriate for children. (J Am Acad Dermatol 2002;47:557-61.)
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Funding sources: None. |
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Conflict of interest: None. |
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Reprint requests: Jörg Schaller, MD, Department of Dermatology, St Barbara Hospital Duisburg, Barbarastr 67, 47167 Duisburg, Germany. |
Vol 47 - N° 4
P. 557-561 - octobre 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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