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Journal of the American Academy of Dermatology
Volume 47, n° 2PB
pages 189-192 (août 2002)
Doi : 10.1067/mjd.2002.108495
Coexistence of pseudoxanthoma elasticum–like papillary dermal elastolysis and linear focal dermal elastosis

Atsushi Akagi, MDa, Shingo Tajima, MDa, Akira Kawada, MDb, Akira Ishibashi, MDa
From the Departments of Dermatology, National Defense Medical College, Saitama,a and Kinki University School of Medicine, Osaka.b 


An 89-year-old Japanese woman had pseudoxanthoma elasticum-like papillary dermal elastolysis on the neck and linear focal elastosis on the flexor aspects of the legs and thighs. The lesions of both diseases had similar histologic patterns-loss of elastic fibers in the papillary dermis and accumulation of normal-appearing elastic fibers in the subpapillary or mid dermis. Immunohistochemical analysis showed elastin, and microfibril-associated proteins (fibrillin 1 and 2 and microfibril associated glycoprotein 1 and 4) were absent or decreased in the papillary dermis and present in the accumulated elastic fibers in both lesions. The association of 2 diseases on different areas of the same patient and histologic and immunohistologic similarities between the diseases suggest that, despite the clinical differences, both diseases are closely related. (J Am Acad Dermatol 2002;47:S189-92.)

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