Complexities of androgen action - 02/09/11
Abstract |
Androgens mediate a wide range of processes during embryogenesis and in the adult. In mammals, the principal androgens are testosterone and its 5⍺-reduced metabolite, 5⍺-dihydrotestosterone (DHT). Although these androgenic hormones are diverse in character, it is believed that their effects are mediated via the protein products of a single androgen receptor gene encoded on the X-chromosome. A great deal of information has now accumulated pertaining to the mechanisms by which nuclear receptors, such as the androgen receptor, modulate the activity of responsive genes. The studies have demonstrated the participation of a number of ancillary proteins in modulating activation or repression by nuclear receptors. In addition to studies focused on the mechanisms of nuclear receptor function, additional work has illuminated the mechanism by which androgens are metabolized in selected tissues. This information provides a perspective on the number of levels of complexity by which differential gene regulation by androgens may occur in different tissues and in different cell types. (J Am Acad Dermatol 2001;45:S87-94.)
Le texte complet de cet article est disponible en PDF.Abbreviations : AR, cDNA, DHT, NCoR, SMRT
Plan
Supported by Robert A. Welch Foundation grant I-1090 and National Institutes of Health grants DK03892 and DK47657. |
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This article is part of a supplement whose publication was supported by an unrestricted educational grant from Pharmacia Consumer Healthcare. |
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Disclosure: The authors attest that they have no conflicts of interest to disclose. |
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Reprint requests: Michael J. McPhaul, MD, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8857. |
Vol 45 - N° 3S
P. S87-S94 - septembre 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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