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Journal of the American Academy of Dermatology
Volume 44, n° 4
pages 689-692 (avril 2001)
Doi : 10.1067/mjd.2001.113462
accepted : 13 February 2001
Linear IgA bullous dermatosis induced by atorvastatin

Cathrin König, Astrid Eickert, Karin Scharfetter-Kochanek, MD, Thomas Krieg, MD, Nicolas Hunzelmann, MD
Department of Dermatology, University of Cologne. Cologne, Germany 


Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disease characterized by circulating IgA antibodies binding the basement membrane zone. In most cases the origin is not clear, but in a minority of cases LABD is drug induced. We describe a patient in whom linear IgA disease developed shortly after beginning therapy with atorvastatin. In Western blotting analysis we detected IgA and IgG class antibodies targeting a 97-kd protein. To our knowledge this is the first reported case of atorvastatin-induced LABD. (J Am Acad Dermatol 2001;44:689-92.)

The full text of this article is available in PDF format.

 Supported by DFG Hu 3/1 and the Köln Fortune program.
 Reprint requests: N. Hunzelmann, MD, Department of Dermatology, University of Cologne, Joseph-Stelzmann-Str 9, 50924 Cologne, FRG. E-mail:
 J Am Acad Dermatol 2001;44:689-92

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