Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light - 02/09/11
Abstract |
Background: Aminolevulinic acid hydrochloride (ALA, Levulan) applied topically to actinic keratoses (AKs) leads to accumulation of the photosensitizer protoporphyrin IX, which, when activated by exposure to light, eradicates AKs. Objective: We examined the safety and efficacy of photodynamic therapy using topical 20% ALA in a solution formulation and varying blue light doses to treat multiple AKs on the face and scalp. Method: This is a multicenter, investigator-blinded, randomized, vehicle-controlled study. Results: Thirty-six patients with clinically typical AKs were treated with 20% ALA; 14 to 18 hours later, they were irradiated with a nonlaser fluorescent blue light source. With the optimal light dose of 10 J/cm2, 88% of the AKs completely cleared 8 weeks after a single photodynamic treatment, compared with 6% after treatment with vehicle and light. Conclusion: Topical ALA PDT using a nonlaser, blue light source is an effective treatment for multiple AKs. (J Am Acad Dermatol 2001;45:96-104.)
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Supported in part by a grant from DUSA Pharmaceuticals, Inc, Valhalla, NY. Dr Jeffes has been a consultant for DUSA Pharmaceuticals but has no financial interest in the company. |
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Reprint requests: Edward W. Jeffes, MD, PhD, Department of Dermatology, C340 Medical Sciences, University of California, Irvine, Irvine, CA 92697. |
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J Am Acad Dermatol 2001;45:96-104 |
Vol 45 - N° 1
P. 96-104 - juillet 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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