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Nutrition clinique et métabolisme
Volume 20, n° 4
pages 185-189 (décembre 2006)
Doi : 10.1016/j.nupar.2006.10.185
Interactions gènes-environnement au cours de la bronchopneumopathie chronique obstructive et l'asthme. Relations avec la composition corporelle
Gene-environment interactions during COPD and Asthma. Relations with body composition
 

Rita Guzun a, b, Christophe Pison a, b,
a Laboratoire de bioénergétique fondamentale et appliquée, Inserm 221, université Joseph-Fourier, Grenoble, France 
b Département de médecine aiguë spécialisée, unité fonctionnelle de pneumologie, hôpital A.-Michalon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France 

Auteur correspondant.
Résumé

Les maladies obstructives pulmonaires fixées comme la BPCO ou réversibles tel l'Asthme sont avant tout des maladies environnementales. Dans ces affections, les interactions gènes-environnement à travers l'épigenèse module la composition corporelle, le niveau de stress oxydant et le risque de développer un trouble ventilatoire obstructif. Il existe ainsi des facteurs environnementaux et génétiques dont les effets pléitropiques rendent compte des relations étroites entre composition corporelle et santé respiratoire.

The full text of this article is available in PDF format.
Abstract

Non-reversible pulmonary obstructive pulmonary diseases as COPD or reversible as asthma are mainly environmental driven diseases. In this context, genes-environment interplays through epigenetics play a role in body composition, the level of oxidant stress and the risk to develop an obstructive bronchial pattern. In this way, they are environmental and genetic factors with pleiotropic effects that might explain the close relationships between body composition and respiratory health.

The full text of this article is available in PDF format.

Mots clés : BPCO, Épigénétique, Gène, Composition corporelle, Index de masse corporelle

Keywords : COPD, Epigenetics, Gene, Body composition, Body Mass Index




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