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Journal of the American Academy of Dermatology
Volume 42, n° 5P1
pages 829-830 (mai 2000)
Doi : 10.1067/mjd.2000.105948
Treatment with anti-tumor necrosis factor ⍺ (TNF-⍺) monoclonal antibody dramatically decreases the clinical activity of psoriasis lesions

Charles J. Oh, MD, Kiron M. Das, MD, PhD, Alice B. Gottlieb, MD, PhD
Divisions of Clinical Pharmacology and Gastroenterology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School. New Brunswick, New Jersey 


We treated a 57-year-old woman for refractory inflammatory bowel disease with a humanized anti–tumor necrosis factor ⍺ monoclonal antibody (Infliximab). The patient also had a 15-year history of Crohn’s disease and a 20-year history of moderate to severe psoriasis. She received a single infusion of Infliximab (5 mg/kg). Two weeks after the infusion her psoriasis had dramatically improved in appearance. To our knowledge, our case is the first reported instance of successful anti–tumor necrosis factor ⍺ therapy in psoriasis. (J Am Acad Dermatol 2000;42:829-30.)

The full text of this article is available in PDF format.

 Reprint requests: Alice B. Gottlieb, MD, PhD, Clinical Research Center, One Robert Wood Johnson Place, Box 19, New Brunswick, NJ 08903. E-mail:

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