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Journal of the American Academy of Dermatology
Volume 42, n° 5P1
pages 835-837 (mai 2000)
Doi : 10.1067/mjd.2000.104890
Treatment of chronic plaque-stage psoriasis and psoriatic arthritis with mycophenolate mofetil

Marcella Grundmann-Kollmann, MDa, Georg Mooser, MDb, Peter Schraeder, MDc, Thomas Zollner, a, Peter Kaskel, MDb, Falk Ochsendorf, MDa, Wolf-Henning Boehncke, MDa, Martina Kerscher, MDb, Roland Kaufmann, MDa, Ralf Uwe Peter, MDb
Frankfurt/Main and Ulm, Germany 
From the Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt/Maina; and the Departments of Dermatologyb and Orthopaedics,c University of Ulm 


Mycophenolate mofetil (MMF), a widely used immunosuppressant in organ transplantation, is a recent addition to the therapeutic armamentarium of autoimmune and inflammatory skin disorders in dermatology. We describe 5 patients with moderate to severe chronic plaque psoriasis and 6 patients with psoriatic arthritis that was refractory to conventional systemic and/or topical antipsoriatic treatment who were treated with MMF monotherapy (2 g/d) in a 10-week study. Although MMF was tolerated well in all patients, only patients with moderate psoriasis and psoriatic arthritis improved with therapy, whereas patients with severe psoriasis did not respond to MMF. Although MMF seems to be effective and safe for blistering autoimmune diseases and pyoderma gangrenosum, our data do not allow optimistic statements on the use of MMF in severe plaque-stage psoriasis. However, MMF may develop into an interesting therapeutic alternative for patients with psoriatic arthritis. (J Am Acad Dermatol 2000;42:835-7.)

The full text of this article is available in PDF format.

 Reprint requests: Marcella Grundmann-Kollmann, Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60596 Frankfurt/Main, Germany.

© 2000  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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