Persistent serpentine supravenous hyperpigmented eruption as an adverse reaction to chemotherapy combining actinomycin and vincristine - 05/09/11
Abstract |
A 15-year-old boy experienced a macular serpentine erythematous eruption that subsided with a persistent hyperpigmentation overlying the superficial venous network of the left forearm. This reaction occurred at the injection site of a chemotherapy regimen that combined actinomycin and vincristine a few hours after the first course. After a single injection of actinomycin in the right arm, a similar reaction occurred, implicating it as the responsible agent. A skin biopsy specimen demonstrated a cell-poor interface tissue reaction associated with an eccrine neutrophilic hidradenitis. To our knowledge, this is the first case of persistent supravenous serpentine hyperpigmented eruption reported in a child treated with this particular drug combination. (J Am Acad Dermatol 2000;43:540–6.)
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Reprint requests: Danielle Marcoux, Hôpital Sainte-Justine, 3175, Côte Ste-Catherine, Montréal, Québec, H3T 1C5, Canada. |
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J Am Acad Dermatol 2000;43:540–6. |
Vol 43 - N° 3
P. 540-546 - septembre 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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