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Journal of the American Academy of Dermatology
Volume 43, n° 4
pages 605-609 (octobre 2000)
Doi : 10.1067/mjd.2000.107234
accepted : 21 Mars 2000
Late metastases of cutaneous melanoma: An analysis of 31 patients
 

Monika-H. Schmid-Wendtner a, Jens Baumert b, Michael Schmidt b, Birger Konz a, Dieter Hölzel b, Gerd Plewig a, Matthias Volkenandt a
Munich, Germany 
From the Department of Dermatology and Allergology,a and Tumor Registry, Department of Medical Informatics, Biometry and Epidemiology,b Ludwig-Maximilians University, Munich 

Abstract

Analysis of data of 6298 patients with cutaneous melanoma seen at the Department of Dermatology and Allergology at the Ludwig-Maximilians University of Munich between 1977 and 1998 identified 31 patients who first experienced metastatic disease 10 or more years after surgical treatment of the primary melanoma. The mean tumor thickness in patients with late progression of disease was 1.4 mm. There was no sex predominance. Of 31 patients, 15 (48.3%) were female and included both premenopausal and postmenopausal women at the time of initial diagnosis without any predominance. Sixteen of the 31 patients (51.6%) with late onset of progression had primary tumors located on the trunk. The prognosis after relapse was related to the site of recurrence; survival after local or regional node recurrence was often prolonged, whereas survival after distant metastases usually was limited. Survival after late recurrence did not correlate with disease-free survival. A high-risk group for late recurrence could not be identified. The data emphasize the value of continued clinical follow-up and self-examination for early detection of regional recurrences. We advocate a lifelong follow-up, also to identify other melanocytic lesions at risk (eg, dysplastic nevi, secondary or multiple melanomas). (J Am Acad Dermatol 2000;43:605-9.)

The full text of this article is available in PDF format.

 Supported by the Bayerisches Staatsministerium fur Landesent-wicklung und Umweltfragen.
 Reprint requests: Matthias Volkenandt, MD, Department of Dermatology and Allergology, Ludwig-Maximilians University, Frauenlobstr 9-11, D-80337 Munich, Germany.
 J Am Acad Dermatol 2000;43:605-9.



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