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Journal of the American Academy of Dermatology
Volume 43, n° 4
pages 631-634 (octobre 2000)
Doi : 10.1067/mjd.2000.107499
accepted : 28 Mars 2000
Raynaud's phenomenon, anticentromere antibodies, and digital necrosis without sclerodactyly: An entity independent of scleroderma?
 

Evelyn M. Sachsenberg-Studer, MD a, Christa Prins, MD b, Jean-Hilaire Saurat, MD b, Denis Salomon, MD b
Frankfurt, Germany, and Geneva, Switzerland 
From the Department of Dermatology, J-W Goethe University Hospital, Frankfurt,a and the Clinic of Dermatology, University Hospital DHURDV, Geneva.b 

Abstract

We describe 4 women of 43, 73, 84, and 86 years with Raynaud's phenomenon, severe digital necrosis, and high serum levels of anticentromere antibodies without skin thickening or internal organ sclerosis. Investigations revealed no diabetes or arterial vascular disease leading to arterial obstruction. Histologic examination did not show any dermal sclerosis or calcinosis. The intravenous infusions of prostaglandin reversed the ischemic lesions in 3 patients. These cases suggest that the triad R aynaud's phenomenon, a ntic entromere a ntibodies and n ecrosis of d igits without sclerodactyly and sclerosis of internal organ should be considered as an entity distinct from scleroderma with sclerosis. For this entity we propose the name RACAND syndrome. (J Am Acad Dermatol 2000;43:631-4.)

The full text of this article is available in PDF format.

 Reprint requests: E. M. Sachsenberg-Studer, MD, Department of Dermatology, J-W Goethe University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt a.M., Germany.
 J Am Acad Dermatol 2000;43:631-4.



© 2000  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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