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Journal of the American Academy of Dermatology
Volume 43, n° 4
pages 683-686 (octobre 2000)
Doi : 10.1067/mjd.2000.106510
Therapeutic update: Use of risperidone for the treatment of monosymptomatic hypochondriacal psychosis

Kathleen B. Elmer, MajUSAF, MC, FS a, Rita M. George, MajUSAF, MC, FS b, Karen Peterson, MajUSAF, MC a
Yokota AB, Japan, and Langley AFB, Virginia 
From the Medical Service, Yokota AB,a and the Dermatology Service, Langley AFB.b 


Monosymptomatic hypochondriacal psychoses such as delusions of parasitosis are often difficult to treat. For the past two decades, pimozide has been considered the drug of choice. Although a few controlled studies have been done to support the efficacy of pimozide, the recommendation of treatment of choice is largely based on case reports. Pimozide has significant side effects, including cardiac and extrapyramidal abnormalities, which are of most concern in the treatment of the elderly. Although pimozide does appear to be effective in some cases of somatic delusional disorders, newer antipsychotics such as risperidone have also been shown to be beneficial in treating this perplexing cluster of disorders. Risperidone is generally considered safer than pimozide and should be considered as first-line therapy for monosymptomatic hypochondriacal psychoses. (J Am Acad Dermatol 2000;43:683-6.)

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 J Am Acad Dermatol 2000;43:683-6.

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