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In vitro assessment of the broad-spectrum ultraviolet protection of sunscreen products - 05/09/11

Doi : 10.1067/mjd.2000.109291 
Brian L. Diffey, DSca, Paul R. Tanner, BSb, Paul J. Matts, PhDc, J.Frank Nash, PhDb
Newcastle upon Tyne and Egham, United Kingdom, and Cincinnati, Ohio 
From the Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tynea; and The Procter & Gamble Company, Sharon Woods Technical Center, Cincinnatib; and The Procter & Gamble Company, Rusham Park Technical Centre, Egham.c 

Abstract

Background: There are considerable data to suggest that protection from solar ultraviolet (UV) radiation will reduce the risk of acute and chronic skin damage in humans. Whereas the sun protection factor (SPF) provides an index of protection against erythemally effective solar UV, largely confined to the UVB (290-320 nm) and short-wavelength UVA (320-340 nm) region, there is currently no agreed-upon method to measure broad-spectrum protection against long-wavelength UVA (340-400 nm). Objective: The objective of these studies was to assess the potential of in vitro UV substrate spectrophotometry and subsequent calculation of the “critical wavelength” value as a measure of broad-spectrum UV protection and as a routine, practical procedure for classification of sunscreen products. Methods: The spectral absorption of 59 commercially available sunscreen products and multiple experimental formulas with one or more UV filters was measured. Sunscreen product, 1 mg/cm2, was applied to a hydrated synthetic collagen substrate, preirradiated with a solar simulator, and then subjected to UV substrate spectrophotometry. Multiple determinations from 5 independent samples per product were used to calculate the critical wavelength value, defined as the wavelength at which the integral of the spectral absorbance curve reached 90% of the integral from 290 to 400 nm. Results: We found that a recognized long-wave UVA active ingredient such as titanium dioxide, zinc oxide, or avobenzone is a necessary but insufficient product requirement for achieving the highest proposed broad-spectrum classification, that is, critical wavelength of 370 nm or more. Although SPF and critical wavelength are largely independent of each other, UVA absorbance must increase commensurate with SPF to maintain the same critical wavelength value. Substrate spectrophotometry and the calculation of critical wavelength can readily account for sunscreen photostability by UV preirradiation. Finally, there is also a strong positive relationship between critical wavelength and a currently available in vivo measure of UVA protection. Conclusion: Determination of critical wavelength by means of UV substrate spectrophotometry provides a rapid, inexpensive, and reliable measure of broad-spectrum protection, which is largely independent of SPF, yet ensures long-wavelength UVA protection commensurate with SPF. The procedure provides a routine, sensitive means of differentiating and classifying sunscreen products and, importantly, obviates the need to subject volunteers to acute exposures of high-dose, nonterrestrial UV, the health risks of which are still poorly understood. (J Am Acad Dermatol 2000;43:1024-35.)

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Abbreviations : AVO:, HSAL:, OCTO:, OMC:, OPABA:, OSAL:, OXY:, PBSA:, PPF:, SPF:, UV:


Plan


 Reprint requests: Professor Brian Diffey, DSc, Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK. E-mail: b.l.diffey@ncl.ac.uk.
 J Am Acad Dermatol 2000;43:1024-35.


© 2000  American Academy of Dermatology, Inc. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 43 - N° 6

P. 1024-1035 - décembre 2000 Retour au numéro
Article précédent Article précédent
  • Double-blind, placebo-controlled study of oral calcitriol for the treatment of localized and systemic scleroderma
  • M.M. Hulshof, J.N.Bouwes Bavinck, W. Bergman, A.A.M. Masclee, L. Heickendorff, F.C. Breedveld, B.A.C. Dijkmans
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