Acral peeling skin syndrome - 05/09/11
Abstract |
Peeling skin syndrome is a rare autosomal recessive disease characterized by widespread painless peeling of the skin in superficial sheets. We describe a 34-year-old man with a lifelong history of spontaneous asymptomatic peeling skin limited to the acral surfaces. This patient probably represents a localized variant of peeling skin syndrome, which has previously been described as a generalized condition. Light and electron microscopic studies of biopsy specimens taken before and after immersion in water were performed. It was concluded that this patient has abnormal keratohyalin granules and inadequate aggregation of keratin filaments that caused the separation of the epidermis in the stratum corneum through the clear zone. Alternatively, unknown keratin species expressed in the clear zone may also cause the abnormality. (J Am Acad Dermatol 2000;43:1112-9.).
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Reprint requests: Ken Hashimoto, MD, Department of Dermatology, 5E-UHC, 4201 St Antoine, Detroit, MI 48201. |
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J Am Acad Dermatol 2000;43:1112-9. |
Vol 43 - N° 6
P. 1112-1119 - décembre 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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