Increased serum levels of soluble vascular cell adhesion molecule 1 and E-selectin in patients with localized scleroderma - 05/09/11
Abstract |
Background: The serum levels of soluble forms of vascular cell adhesion molecule 1 (sVCAM-1) and E-selectin (sE-selectin) can be used as a marker of endothelial activation. Objective: We investigated whether the serum level of sVCAM-1 and sE-selectin in patients with localized scleroderma (LSc) was correlated with the clinical or serologic features of this disease. Methods: Serum samples from 59 patients with LSc, 20 patients with systemic sclerosis (SSc) and 29 healthy controls were examined using specific enzyme-linked immunosorbent assays. Results: The serum levels of sVCAM-1 and sE-selectin in patients with LSc were significantly higher than those of the healthy controls. The serum levels of sVCAM-1 and sE-selectin were correlated with both the number of sclerotic lesions and the number of involved areas. Conclusion: These results indicate that the serum levels of sVCAM-1 and sE-selectin may reflect the extent of the skin involvement (ie, the disease severity) and may be useful for monitoring the in vivo states of endothelial activation in LSc. (J Am Acad Dermatol 2000;42:64-9.)
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Reprint requests: H. Ihn, MD, Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: IN-DER@h.u-tokyo.ac.jp. |
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0190-9622/2000/$12.00 + 0 16/1/102363 |
Vol 42 - N° 1P1
P. 64-69 - janvier 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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