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Journal of the American Academy of Dermatology
Volume 42, n° 3
pages 519-520 (mars 2000)
Doi : 10.1016/S0190-9622(00)90233-0
Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent

Takeshi Kono, MDa, Masamitsu Ishii, MDa, Nobuo Negoro, MDb, Shoji Taniguchi, MDc
Osaka, Japan 
From the Department of Dermatologya and the First Department of Internal Medicine,b Osaka City University Medical School, and the Department of Dermatology,c Osaka General Hospital of the West Japan Railway Company 


UFT, a combination of uracil and tegafur, is a second-generation anticancer agent. UFT has been used in Japan, other Asian countries, South America, and Russia. Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially with leukovorin. We report a case of a scleroderma-like reaction induced by long-term administration of UFT. This is the first report of UFT-induced scleroderma-like reaction. (J Am Acad Dermatol 2000;42:519-20.)

The full text of this article is available in PDF format.

 Reprint requests: Takeshi Kono, MD, Department of Dermatology, Osaka City University Medical School, 1-4-7, Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

© 2000  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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