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Journal of the American Academy of Dermatology
Volume 42, n° 5P2
pages 903-906 (mai 2000)
Doi : 10.1016/S0190-9622(00)90269-X
Reactive angioendotheliomatosis in association with the antiphospholipid syndrome
 

Daniel Creamer, MRCP, Martin M. Black, MD, Eduardo Calonje, MD
St John’s Institute of Dermatology, St Thomas’ Hospital, London, UK. London, United Kingdom 

Abstract

A 50-year-old woman with systemic lupus erythematosus developed extensive necrotic skin lesions on her chest and abdomen after the discontinuation of warfarin. The presence of antiphospholipid antibodies suggested a diagnosis of antiphospholipid syndrome. Histopathology from a skin lesion demonstrated marked expansion of the dermal microvasculature by intravascular cellular proliferation and focal thrombosis. The intravascular cells stained positive for the endothelial cell markers CD31 and factor VIII-associated antigen confirming reactive angioendotheliomatosis (RAE). This report is the first to identify RAE occurring in the context of the antiphospholipid syndrome. We suggest that intravascular endothelial proliferation, in concert with thrombosis, contributed to the angio-occlusive pathology. (J Am Acad Dermatol 2000;42:903-6.)

The full text of this article is available in PDF format.

 This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology.
 Reprint requests: Eduardo Calonje, MD, Department Dermatopathology, St John’s Institute of Dermatology, St Thomas’ Hospital, London SE1 7EH, UK. E-mail: j.calonje@umds.ac.uk .



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